منابع مشابه
When man got his mtDNA deletions?
Somatic mtDNA mutations and deletions in particular are known to clonally expand within cells, eventually reaching detrimental intracellular concentrations. The possibility that clonal expansion is a slow process taking a lifetime had prompted an idea that founder mutations of mutant clones that cause mitochondrial dysfunction in the aged tissue might have originated early in life. If, converse...
متن کاملResponse to: ‘when man got his mtDNA deletions?’
Sean D. Taylor, Jesse J. Salk and Jason H. Bielas Translational Research Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, Seattle, WA 98109, USA Department of Medicine, University of Washington Medical Center, 1959 NE Pacific St, Seattle, WA 98195, USA Department of Pathology, University of Washington Medical Center, 1959 NE Pacific St, Seattl...
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Neurobrucellosis (N.B) is a rare and severe form of systemic Brucella infection. We introduced an unusual case that “Psychologic Symptoms” was the most prominent complaints of his family. He was a 50-year-old man who has worked in butchery. His problems had begun 2 months prior to his admission with mood disorders, arthralgia, weakness, headache, and night sweats; he has recurrent crying with n...
متن کاملMan and his spaceships
The resiliency and adaptive ability of microbial life in real time on Earth relies heavily upon horizontal gene transfer. Based on that knowledge, how likely is earth based microbial life to colonize extraterrestrial targets such as Mars? To address this question, we consider manned and unmanned space exploration, the resident microbiota that is likely to inhabit those vehicles, the adaptive po...
متن کاملMan and His Future
The subject matter of this Ciba symposium departs from the usual specialized, esoteric topics of these meetings. Bringing together such noted scientists as Sir Julian Huxley, Joshua Lederberg, Albert Szent-Gy6rgi, and J. B. S. Haldane, this conference discusses the future of mankind as seen through the eyes of people actively engaged in biological research. These men don the philosopher's hat a...
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ژورنال
عنوان ژورنال: Aging Cell
سال: 2014
ISSN: 1474-9718,1474-9726
DOI: 10.1111/acel.12231